HyaGlo® Skin Serum is made with hyaluronan, a unique substance naturally produced by the body for tissue hydration. Interest is ever-increasing for cosmeceuticals that aid in combating fine lines, wrinkles, and dry skin. Unlike other moisturizers that only temporarily alleviate surface tissue dryness, repeated applications of HyaGlo provide long-term skincare by addressing the source of the concern. Unlike abrasive substances or hazardous chemicals found in some cosmetics, hyaluronan is well tolerated by the body for skincare.
Hyaluronan is the accepted scientific nomenclature for hyaluronic acid (HA) and physiological salts of hyaluronate, the conjugate base of hyaluronic acid. Hyaluronan is classified as a glycosaminoglycan (GAG), a long, unbranched polysaccharide made of repeating disaccharides of glucuronic acid and glucosamine (Fraser, 1997). The polymer chain of hyaluronan ranges in molecular weight from hundreds of units (or Daltons) up to several million.
Hyaluronan is found ubiquitously throughout the mammalian body. It is either directly or indirectly involved in every physiological function of the body. It is found in dense concentrations in cartilage, synovial fluid, skin, vertebral discs, bones, urinary tract, cardiac valves, eyes, and various other soft tissue. Hyaluronan is most abundant during embryogenesis and declines in overall quantity and quality throughout life (McDonald, 2002).
One of the primary functions of hyaluronan is maintaining tissue hydration. Interestingly, hyaluronan is so hydrophilic it can absorb, retain, and deliver over one-thousand times its weight in water (Wand, 2007). The ubiquitous nature of the molecule ensures that hydrophilic delivery takes place throughout all tissue.
Hyaluronan is found most prevalently in the skin; approximately half of total body hyaluronan is located within the dermal and epidermal layers. Primary functions of hyaluronan in the skin include moisturization and hydration (Meyer, 1941). Skin turgor is the result of the ability of hyaluronan to absorb, retain, and deliver water (Wang, 2007). With age, there is a distinct decrease in the percent composition of hyaluronan in epidermal tissue likely correlating with the increase in wrinkles and aged skin (Juhlin, 1997) Experiments have demonstrated that 77% of naturally occurring hyaluronan in the skin is lost by age 70 in humans (Weist, 2008).